Mean Platelet Volume in Patients with Acute Coronary Syndromes:
A Supportive Diagnostic Predictor
Published: August 1, 2014 | DOI: https://doi.org/10.7860/JCDR/2014/.4650
Randheer Pal, Rajeev Bagarhatta, Sandhya Gulati, Monika Rathore, Nidhi Sharma
1. Senior Cardiologist, Department of Cardiology, SMS Medical College, Jaipur, Rajasthan, India.
2. Professor, Department of Cardiology, SMS Medical College, Jaipur, Rajasthan, India.
3. Associate Professor, Department of Pathology, SMS Medical College, Jaipur, Rajasthan, India.
4. Associate Professor, Department of Community Medicine, SMS Medical College, Jaipur, Rajasthan, India.
5. Senior Pathologist,Department of Pathology, SMS Medical College, Jaipur, Rajasthan, India.
Correspondence
Dr. Randheer Pal,
C/o Sharvan Gurjar A-1, Pratap Nagar, Shastri Nagar, Jaipur, Rajasthan, India.
Phone: 09660245770, E-mail: randheerpal@gmail.com
Background: Platelets and their activity have a crucial role in acute coronary events. Larger platelets are enzymatically and metabolically more active and have a higher potential thrombotic ability as compared with smaller platelets.
Objectives: The aim of this study is to investigate whether there is an association between mean platelet volume (MPV) measurement and cardiac Troponin I( cTn I ) in patients admitted with a suspected diagnosis of ACS and to assess the potential diagnostic efficiency of MPV in the diagnostic workup for ACS.
Materials and Methods: After thorough evaluation of 215 eligible patients, 3 ml. Venous blood collected using Becton, Dickinson and company vacutainer and MPV measured within 1-2 hr of sample collection. Sample for cTn I collected at 6 hr and at 12 hrs, if required and level measured using Biosite analyzer.
Results: Mean platelet volume (MPV) was found to be higher among ACS patients as compared to non ACS, 11.44±1.23 vs 9.91±1.27 fl (p-value<0.001). The NPV of MPV in the diagnostic workup of chest pain suggestive of ACS within 6 hours of presentation were found to be 82.53%.
Conclusion: In this study the MPV is significantly higher in patients with ACS than in those with chest pain of non-cardiac origin and its negative predictive value of 82.53%, it might be useful as an assisting rule-out test in conjunction with other markers in the early prediction of the risk of ACS.
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